Suchergebnisse
13. Nov. 2017 · PD1 limits the activation and function of potentially pathogenic self-reactive CD4 + and CD8 + T cells, and PDL1 can shield target organs from autoimmune attack. Due to the diverse roles of the...
- Full Size Image
We would like to show you a description here but the site...
- Full Size Table
We would like to show you a description here but the site...
- Nobel Prize in Physiology Or Medicine 2018
The 2018 Nobel Prize in Physiology or Medicine was awarded...
- Full Size Image
31. Aug. 2020 · The interaction between PD-1 and PD-L1 inhibits antitumor T cell immunity by impairing effector T cell activation, and PD-1–PD-L1 blockade reactivates antitumor T cell immunity,...
- Shogo Kumagai, Yosuke Togashi, Takahiro Kamada, Eri Sugiyama, Hitomi Nishinakamura, Yoshiko Takeuchi...
- 2020
21. Juni 2023 · Extrathymic peripheral T cell tolerance prevents aberrant responses by CD8 T cells that are specific for self-antigens or harmless non-self-antigens 1,2. Both T cell-intrinsic...
PD-1 inhibits antigen-dependent activation of T cells to suppress immune responses against self-tissues and tumors. Shimizu et al. investigate how PD-1 affects transcriptome changes in T cells and discover that PD-1 preferentially inhibits upregulation of genes that are less efficiently induced by antigen receptor signal.
- Xing He, Chenqi Xu
- 2020
8. Jan. 2020 · PD-1 inhibits antigen-dependent activation of T cells to suppress immune responses against self-tissues and tumors. Shimizu et al. investigate how PD-1 affects transcriptome changes in T cells and discover that PD-1 preferentially inhibits upregulation of genes that are less efficiently induced by antigen receptor signal.
- Kenji Shimizu, Kenji Shimizu, Daisuke Sugiura, Daisuke Sugiura, Il-mi Okazaki, Il-mi Okazaki, Takumi...
- 2020
1. Okt. 2022 · Mechanistic studies indicated that PD-L2 could competitively inhibit PD-L1 to PD-1 activity and promote CD3 and inducible co-stimulator (ICOS) expression on T cells, which further induced effective CD4 + T cell immune response.
28. Apr. 2024 · PD-1 receptors on immune cells engage with one of its ligands, PD-L1 or PD-L2, expressed on antigen-presenting cells or tumor cells, driving T-cell dysfunction and tumor immune escape. Thus, targeting PD-1/PD-L1 revitalizes cytotoxic T cells for cancer elimination.
