Suchergebnisse
19. Mai 2004 · After the completion of CSR, postswitch transcript (PST) containing intervening µ (Iµ) and each of the switched C H exons is expressed 1,2,3,4.
- Akihiko Muto, Satoshi Tashiro, Osamu Nakajima, Hideto Hoshino, Hideto Hoshino, Satoru Takahashi, Eii...
- 2004
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8. Aug. 2020 · To delineate the nature of the Ig deficiency, we directly assessed the generation of postswitch transcripts and found a decrease for IgG1, IgE, IgG3, and Ig2a for postswitch transcripts in purified CD19+ B cells derived from Lsh Vav KO mice compared to Ctrl (Fig. 3 O and P).
- Yafeng He, Jianke Ren, Xiaoping Xu, Kai Ni, Andrew Schwader, Richard Finney, Can Wang, Lei Sun, Kimb...
- 10.1073/pnas.2004112117
- 2020
- 2020/08/08
1. Apr. 2006 · Using standard PCR conditions with primers specific for CDR2 or CDR3 and IgH constant regions for 30 cycles of PCR, as previously reported, 6 postswitch clonal isotypes were undetectable before or after in vitro stimulation of CSR.
- Jitra Kriangkum, Brian J. Taylor, Brian J. Taylor, Erin Strachan, Erin Strachan, Michael J. Mant, Mi...
- 2006
16. Apr. 2002 · We show here a role for T-bet in the regulation of IgG class switching, especially to IgG2a. T-bet-deficient B lymphocytes demonstrate impaired production of IgG2a, IgG2b, and IgG3 and, most strikingly, are unable to generate germ-line or postswitch IgG2a transcripts in response to IFN-γ.
29. Juli 2020 · To delineate the nature of the Ig deficiency, we directly assessed the generation of postswitch transcripts and found a decrease for IgG1, IgE, IgG3, and Ig2a for postswitch transcripts in purified CD19+ B cells derived from Lsh Vav KO mice compared to Ctrl (Fig. 3 O and P).
12. Sept. 2006 · Germline (GL) transcription is regulated by specific promoters and immunoglobulin heavy chain ( IgH) 3′ locus enhancers and is necessary for Ig class-switch recombination (CSR). We have generated different transgenic lines containing the GL ϵ promoter, switch (S) ϵ region, and constant (C) ϵ region with or without the DNase I ...
